Estimation of whole-body RNA catabolism based on the urinary modified nucleoside levels of cancer and AIDS patients. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Estimation of whole-body RNA catabolism based on the urinary modified nucleoside levels of cancer and AIDS patients.

Nucleic Acids Symp Ser. 1991;(25):125-6. Unique Identifier : AIDSLINE MED/93065251
Nakano K; Nakao T; Schram KH; Hammargren WM; PL Comprehensive Research Institute, Osaka, Japan.

Abstract: From the relationship between the molar ratio of nucleosides calculated stoichiometrically from modified nucleoside occurrences in major RNA species and the proportion of rRNA to all of RNA contents in average tissues, the increase of rRNA contents in cancer tissues growing rapidly was found. Thus, we found that selected urinary modified nucleoside levels were very useful as a biological marker of cancer and AIDS, as well as a good indicator of whole-body metabolic conditions of RNAs.
Keywords: Acquired Immunodeficiency Syndrome/*METABOLISM/URINE Biological Markers/URINE Human Intestinal Neoplasms/*METABOLISM/SURGERY/URINE Nucleosides/*URINE RNA/*METABOLISM Stomach Neoplasms/*METABOLISM/SURGERY/URINE Tumor Markers, Biological/URINE JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDmetabolism/urinebiologicalmarkers/urinehumanintestinalneoplasms/KWDmetabolism/surgery/urinenucleosides/KWDurinerna/KWDmetabolismstomachneoplasms/KWDmetabolism/surgery/urinetumormarkers,biological/urinejournalarticle
930228
M9320846

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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