Progressive multifocal leukoencephalopathy in HIV-1-infected children. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Progressive multifocal leukoencephalopathy in HIV-1-infected children.

AIDS. 1992 Aug;6(8):837-41. Unique Identifier : AIDSLINE MED/93039869
Berger JR; Scott G; Albrecht J; Belman AL; Tornatore C; Major EO; Department of Neurology, University of Miami School of Medicine,; Florida 33136.

Abstract: OBJECTIVE: To describe the clinical and pathologic features of two HIV-1-infected children with progressive multifocal leukoencephalopathy (PML). DESIGN: Case report. SETTING: University-affiliated, public-health trust hospital. METHODS: Two HIV-1-infected children with PML are described. A 13-year-old girl, presumed to be congenitally infected with HIV-1, presented with dysarthria and paresthesias of the tongue and chin that evolved rapidly to dementia, muteness and severe spastic quadriparesis. The other patient, a 10-year-old boy who developed HIV-1 infection from a blood transfusion at the age of 3 years, presented with a facial palsy with subsequent development of right hemiparesis and aphasia. RESULTS: Brain biopsy in the first child and autopsy in the second confirmed the diagnosis of PML. In both patients, the CD4 T-lymphocyte count was less than 100 x 10(6)l at the time of neurological presentation. CONCLUSION: Despite seroepidemiological studies suggesting that the majority of individuals are infected with JC virus during childhood, PML is rare in children with impaired cell-mediated immunity. Our patients illustrate that PML is among the neurological complications of HIV-1 infection in children.
Keywords: Adolescence Brain/*PATHOLOGY Case Report Child Female Human HIV Infections/*COMPLICATIONS *HIV-1 Leukoencephalopathy, Progressive Multifocal/MICROBIOLOGY/ *PATHOLOGY Male Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDadolescencebrain/KWDpathologycasereportchildfemalehumanhivinfections/KWDcomplicationsKWDhiv-1leukoencephalopathy,progressivemultifocal/microbiology/KWDpathologymalesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
930228
M9320825

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1993. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1993. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .