Serologic prevalence of selected infectious diseases in cats with uveitis. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Serologic prevalence of selected infectious diseases in cats with uveitis.

J Am Vet Med Assoc. 1992 Oct 1;201(7):1005-9. Unique Identifier : AIDSLINE MED/93053942
Lappin MR; Marks A; Greene CE; Collins JK; Carman J; Reif JS; Powell CC; Department of Clinical Sciences, College of Veterinary Medicine; and Biomedical Sciences, Colorado State University, Fort Collins; 80523.

Abstract: Serologic evidence of infection by Toxoplasma gondii, feline leukemia virus, feline coronaviruses, or feline immunodeficiency virus (FIV) is commonly found in cats with uveitis. Serum samples from 124 cats with uveitis were assayed by use of ELISA for the detection of T gondii-specific immunoglobulin M (IgM), IgG, and circulating antigens (Ag), as well as an ELISA for feline leukemia virus Ag, an ELISA for antibodies to FIV, and an indirect fluorescent antibody assay for antibodies to feline coronaviruses. Serologic evidence of infection by 1 or more of the infectious agents was detected in 83.1% of the samples. Serologic evidence of T gondii infection, defined as the detection of T gondii-specific IgM, IgG, or Ag in serum, was found in 74.2% of the samples. The seroprevalence of T gondii infection was significantly greater in cats with uveitis than in healthy cats from a similar geographic area. Serum samples from cats with serologic evidence of both T gondii and FIV infections were more likely to contain T gondii-specific IgM without IgG than samples from cats with serologic evidence of T gondii infection alone. Cats with serologic evidence of FIV and T gondii coinfection had a higher T gondii-specific IgM titer geometric mean and a lower T gondii-specific IgG titer geometric mean than did cats with serologic evidence of T gondii infection alone. Serologic evaluation for T gondii infection should include assays that detect IgM, IgG, and Ag, particularly in cats coinfected with FIV.
Keywords: Animal Antibodies, Protozoan/BLOOD Antibodies, Viral/BLOOD Antigens, Protozoan/BLOOD Antigens, Viral/BLOOD Cat Diseases/*EPIDEMIOLOGY Cats Coronaviridae/IMMUNOLOGY Coronaviridae Infections/COMPLICATIONS/EPIDEMIOLOGY/VETERINARY Eye Infections, Viral/COMPLICATIONS/EPIDEMIOLOGY/VETERINARY Feline Acquired Immunodeficiency Syndrome/COMPLICATIONS/ EPIDEMIOLOGY Female Immunodeficiency Virus, Feline/IMMUNOLOGY Immunoglobulins/BLOOD Immunologic Tests Leukemia Virus, Feline/IMMUNOLOGY Male Prevalence Toxoplasma/IMMUNOLOGY Toxoplasmosis, Ocular/COMPLICATIONS/EPIDEMIOLOGY/*VETERINARY Uveitis/COMPLICATIONS/*VETERINARY Virus Diseases/COMPLICATIONS/EPIDEMIOLOGY/*VETERINARY JOURNAL ARTICLEKWDanimalantibodies,protozoan/bloodantibodies,viral/bloodantigens,protozoan/bloodantigens,viral/bloodcatdiseases/
930228
M9320185

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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