Adult T-cell leukemia and spastic paraparesis in south India: molecular epidemiology of HTLV-I (Meeting abstract).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Adult T-cell leukemia and spastic paraparesis in south India: molecular epidemiology of HTLV-I (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A3239 1993. Unique Identifier : AIDSLINE ICDB/93694195
Nerurkar VR; Song KJ; Babu PG; Saraswathi NK; Chandy M; John TJ; Yanagihara R; NIH, Bethesda, MD 21702

Abstract: Until recently, the occurrence of human T-lymphotropic virus type I (HTLV-I) infection and disease was controversial in India. We have recently identified cases of HTLV-I-associated adult T-cell leukemia and spastic paraparesis among residents of south India. Our serological surveys have also uncovered HTLV-I carriers and 2 individuals dually infected with HTLV-I and HIV-1. To clarify the genomic heterogeneity of HTLV-I strains from south India, we amplified selected regions of the gag, pol and env genes in DNA extracted from whole blood blotted onto filter paper. Sequence analysis and comparison of these HTLV-I strains with those of cosmopolitan strains of HTLV-I revealed that the HTLV-I strains from south India were 98.9% similar to the Japanese prototype HTLV-I ATK. All base substitutions were silent, and no frame shifts or disease-specific base changes were found. Dendrograms based on 1287 bases indicated that the south Indian HTLV-I strains clustered with those from Japan, suggesting a common origin or source with subsequent parallel evolution. Further molecular genetic studies of HTLV-I and HIV from India, now underway, may provide additional insights into the early and recent dissemination of these retroviruses.

Keywords: Carrier State DNA, Viral Genes, env Genes, gag Genes, pol Human HTLV-I Infections/EPIDEMIOLOGY/*GENETICS/TRANSMISSION India/EPIDEMIOLOGY Paraparesis, Tropical Spastic/EPIDEMIOLOGY/*GENETICS ABSTRACT
931230
M93C0829

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