Characterization of LP-BM5 defective retrovirus-induced T-cell lymphomagenesis in murine acquired immunodeficiency disease (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Characterization of LP-BM5 defective retrovirus-induced T-cell lymphomagenesis in murine acquired immunodeficiency disease (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A3257 1993. Unique Identifier : AIDSLINE ICDB/93694216
Campbell-Washington J; Eiseman JL; MacAuley C; Sentz D; Univ. of Maryland Cancer Center, Baltimore, MD 21201

Abstract: Murine acquired immunodeficiency syndrome (MAIDS) is induced by infection of susceptible mice (ie, C57BL/6) with LP-BM5, a mixture of murine leukemia viruses (MuLV). The syndrome is characterized by severe immunodeficiency and lymphoproliferation termed MAIDS because of its similarity to human AIDS. Preliminary results have indicated that clonal T cell, rather than B-cell lymphoblastic lymphomas arose at high frequency (61%) in C57BL/6 mice with full-blown MAIDS. The progressive course of poly- to oligoclonality has been traced by the molecular analysis of immunoglobulin and TCR gene rearrangements, as well as proviral integration site analyses. Immunophenotypic profiles, malignant potential and transplantability in SCID and syngeneic recipients of these lymphomas are detailed in this study. The results demonstrated that clonal populations of predominately CD4+ T cells with malignant potential was established at high frequency in late-stage MAIDS.
Keywords: Animal Gene Rearrangement Genes, Immunoglobulin Immunophenotyping Lymphoproliferative Disorders/*COMPLICATIONS Mice Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome/*COMPLICATIONS Receptors, Antigen, T-Cell/GENETICS ABSTRACTKWDanimalgenerearrangementgenes,immunoglobulinimmunophenotypinglymphoproliferativedisorders/KWDcomplicationsmicemice,inbredc57blmurineacquiredimmunodeficiencysyndrome/KWDcomplicationsreceptors,antigen,t-cell/geneticsabstract
931230
M93C0827

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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