Excess risk of leukemia among persons with the acquired immune deficiency syndrome (AIDS) (Meeting abstract).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Excess risk of leukemia among persons with the acquired immune deficiency syndrome (AIDS) (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 12:A5 1993. Unique Identifier : AIDSLINE ICDB/93694405
Manns A; Cote T; Biggar R; Blattner W; NACMR Study Group, NCI, Bethesda, MD 20892

Abstract: Since leukemia occurs in the setting of immune deficiency, we evaluated the possibility that leukemias may occur at increased frequency in persons with AIDS compared to the general population. Cancer and AIDS registries were linked in four States and age-, sex-, and race-adjusted expected (Exp) numbers of leukemias, in time periods relative to AIDS diagnosis (dx), were computed and compared to observed linkages to determine risk (O/E) estimates. Comparison of cases in relationship to AIDS diagnosis is presented in a table. The median age at dx of the leukemias (N=30) was 37 yr, 70% were white, 90% were males and 80% were gay/bisexual males, the predominant transmission risk group. 30% of cases had non-Hodgkin's lymphoma (NHL; n=9) as the AIDS-defining illness, 8/9 NHL cases had a concurrent dx of acute lymphocytic leukemia (ALL), with only 1/9 cases associated with an acute nonlymphocytic leukemia (ANLL). Overall median survival from time of AIDS dx was 4 mo and from time of leukemia dx was 3.3 mo; with ALL and ANLL having median survival of 3.4 mo and 2.3 mo, respectively. While our data suggest that the risk of leukemia at time of AIDS dx is in part due to leukemic manifestation of NHL, about one-half are ANLL unrelated to NHL. Before we can conclude that prolonged immune deficiency places persons with AIDS at risk for development of ANLL and other leukemias, issues of ascertainment bias and potential case misclassification must be addressed.

Keywords: Acquired Immunodeficiency Syndrome/*MORTALITY Adult *Cause of Death Female Follow-Up Studies Human Leukemia, Lymphocytic, Acute/*MORTALITY Leukemia, Nonlymphocytic, Acute/*MORTALITY Lymphoma, AIDS-Related/MORTALITY Male Risk Factors Survival Rate ABSTRACT
931230
M93C0822

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