Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
Non-AIDS-defining malignancies occurring in individuals who have immunodeficiency virus infection (Meeting abstract).
Proc Annu Meet Am Soc Clin Oncol; 12:A14 1993. Unique Identifier : AIDSLINE ICDB/93694414 Toi M; Myers AM; Univ. of Colorado Health Sciences Center, Denver, CO 80204
Abstract:
28 non-AIDS-defining malignancies occurring in 27 individuals with human immunodeficiency virus infection were identified at the University of Colorado Health Sciences Center and its affiliated hospitals from 1988 through 1992. An individual with both Hodgkin's disease and malignant melanoma was seen in 1984. The age range of these patients (pts) at diagnosis was 25 through 72 yr with a mean age of 38 yr. The most common malignancy was Hodgkin's disease which occurred in seven individuals. Five pts had cutaneous malignancies including three with malignant melanoma. Three had germ cell tumors, 3 had anal rectal cancers, 2 had multiple myeloma, and 2 had lung cancers. The remaining pts had a variety of malignancies including cancers of the pancreas, breast, liver, brain, bladder and metastatic carcinoid. The mean CD4 lymphocyte count at time of diagnosis was 244 cells/mm3 indicating that, in general, pts were not in advanced stages of HIV infection when their cancers were detected. A common feature of the cancers of these individuals included their occurrence at an unusually young age, ie, breast cancer in a 31-yr-old male, multiple myeloma in a 28-yr-old, and anorectal cancer in two men 30 and 34 yr of age. Also, most tumors were in advanced stages at diagnosis and had an aggressive course. Comorbid conditions associated with the immunodeficiency of HIV infection made management of these individuals difficult. Chemotherapy, when it was part of the treatment regimen, was also uniformly poorly tolerated. Difficulty was encountered maintaining treatment at scheduled doses and at appropriate intervals because of poor bone marrow tolerance. It also was found that many pts treated with chemotherapy did not respond well. Four of 7 pts with Hodgkin's disease died with active disease while receiving therapy. The mean survival from diagnosis of malignancy to death of the 11 pts who have died was only 6.5 mo. It was found that hospital tumor registries often failed to identify pts' HIV status prior to 1992, while the AIDS surveillance data did not report the occurrence of non-AIDS-defining conditions. The information from these registries was difficult to collate in order to identify individuals with HIV infection who had non-AIDS-defining malignancies. Our experience suggests the need for a National Registry for such a purpose.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DIAGNOSIS/ MORTALITY Adult Aged Cause of Death Female Follow-Up Studies Human Lymphoma, AIDS-Related/COMPLICATIONS/DIAGNOSIS/MORTALITY Male Middle Age Neoplasms/*COMPLICATIONS/DIAGNOSIS/MORTALITY Survival Rate ABSTRACT 931230
M93C0815
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Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
