Interleukin-6 and granulocyte macrophage-CSF in the cerebrospinal fluid from HIV infected subjects with involvement of the central nervous system. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Interleukin-6 and granulocyte macrophage-CSF in the cerebrospinal fluid from HIV infected subjects with involvement of the central nervous system.

Arq Neuropsiquiatr. 1992 Jun;50(2):180-2. Unique Identifier : AIDSLINE MED/93371156
Perrella O; Guerriero M; Izzo E; Soscia M; Carrieri PB; D. Cotugno Hospital for Infectious Diseases, Naples.

Abstract: We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.
Keywords: Adult AIDS Dementia Complex/BLOOD/*CEREBROSPINAL FLUID Central Nervous System Diseases/BLOOD/CEREBROSPINAL FLUID Comparative Study Enzyme-Linked Immunosorbent Assay Female Granulocyte-Macrophage Colony-Stimulating Factor/BLOOD/ *CEREBROSPINAL FLUID Human Interleukin-6/BLOOD/*CEREBROSPINAL FLUID Male Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadultaidsdementiacomplex/blood/KWDcerebrospinalfluidcentralnervoussystemdiseases/blood/cerebrospinalfluidcomparativestudyenzyme-linkedimmunosorbentassayfemalegranulocyte-macrophagecolony-stimulatingfactor/blood/KWDcerebrospinalfluidhumaninterleukin-6/blood/KWDcerebrospinalfluidmalesupport,non-uKWDsKWDgov'tjournalarticle
931230
M93C0794

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