[Plasmapheresis in neurology. Critical analysis of indications and protocols] NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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[Plasmapheresis in neurology. Critical analysis of indications and protocols]

Arq Neuropsiquiatr. 1992 Sep;50(3):324-8. Unique Identifier : AIDSLINE MED/93371182
Seggia JC; Abreu P; Hospital dos Servidores do Estado INAMPS-RJ, Brasil.

Abstract: Therapeutic plasmapheresis (plasma exchange) in neurology is a matter of discussion. We review the main articles on clinical trials, both controlled and uncontrolled, trying to establish the efficacy and safety of the procedure. Humoral aspects involved in the genesis of the disorder play an important role for its indication in the present time. In myasthenia gravis indications for plasmapheresis are established: in the preparation for thymectomy, in patients with respiratory insufficiency and requiring respiratory prosthesis, after long immunosuppression therapy with rebound effect, when all other forms of therapy failed, and in neonatal myasthenia gravis with special technics. We discuss the indication of plasmapheresis in Guillain-Barre syndrome, multiple sclerosis, chronic inflammatory demyelinating polyneuromyelopathy, HTLV-1 myelopathy, HIV peripheral neuropathy and myelopathy, paraproteinemias, polymyositis, and dermatomyositis. Indications for other diseases are mentioned. Reference is made to the results we observed in 31 cases followed consecutively at Hospital dos Servidores, Rio de Janeiro, from June 1984 to June 1990. In our series 26 were myasthenic patients, 4 patients presented Guillain-Barre syndrome, and 1 multiple sclerosis. Therapeutic plasmapheresis protocols suggested by us are summarized.
Keywords: Adolescence Adult Aged Child Clinical Protocols English Abstract Female Human Male Middle Age Nervous System Diseases/*THERAPY *Plasmapheresis JOURNAL ARTICLEKWDadolescenceadultagedchildclinicalprotocolsenglishabstractfemalehumanmalemiddleagenervoussystemdiseases/KWDtherapyKWDplasmapheresisjournalarticle
931230
M93C0791

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