CSF in 85 patients with AIDS and CNS cryptococcosis. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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CSF in 85 patients with AIDS and CNS cryptococcosis.

Arq Neuropsiquiatr. 1992 Dec;50(4):491-6. Unique Identifier : AIDSLINE MED/93393457
Livramento JA; Machado LR; Nobrega JP; Gomes HR; Vianna LS; Spina-Franca A; CIN Neurology Investigation Center, Department of Neurology,; Faculty of Medicine, Sao Paulo University, Brasil.

Abstract: In an eight years time period (July 1984-June 1992) CSF samples of 40718 patients were studied, and 610 were from patients with AIDS clinically diagnosed and immunologically confirmed through HIV antibodies detection. Among opportunistic infections detected in them 85 were CNS cryptococcosis. For the purpose of this study the CSF of these 85 patients are the AIDS group of CNS cryptococcosis. For comparison, CSF data from 50 patients with CNS cryptococcosis but without AIDS were taken (non-AIDS group); in this group, 22 patients were immunosuppressed after renal transplant. In AIDS group, the more frequent CSF findings were: yeast presence at direct exam (Fuchs-Rosenthal cell counting chamber), growing of the yeast in cultures, and gamma globulins increase. In non-AIDS group were more frequent: hypercytosis, neutrophil cells presence, and total protein increase. Differences between the two groups are discussed taking into account CNS/CSF immune changes induced by HIV infection. It is concluded that in CNS cryptococcosis of patients with AIDS the CSF evidenced more extensive signs of the fungal opportunistic infection than signs of inflammatory response to the infection. The latter were more prominent among patients of the non-AIDS group of CNS cryptococcosis.
Keywords: Acquired Immunodeficiency Syndrome/*CEREBROSPINAL FLUID/ COMPLICATIONS Adolescence Adult Aged Brain Diseases/*CEREBROSPINAL FLUID/COMPLICATIONS Child Comparative Study Cryptococcosis/*CEREBROSPINAL FLUID/COMPLICATIONS Female Human Kidney Transplantation Male Middle Age JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDcerebrospinalfluid/complicationsadolescenceadultagedbraindiseases/KWDcerebrospinalfluid/complicationschildcomparativestudycryptococcosis/KWDcerebrospinalfluid/complicationsfemalehumankidneytransplantationmalemiddleagejournalarticle
931230
M93C0770

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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