Molecular and biological diversity of HIV-1 in Brazil. NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Molecular and biological diversity of HIV-1 in Brazil.

Mem Inst Oswaldo Cruz. 1992 Apr-Jun;87(2):249-55. Unique Identifier : AIDSLINE MED/93375901
Couto-Fernandez JC; Morgado MG; dos Santos JI; Galvao-Castro B; Laboratorio Avancado de Saude Publica, Centro de Pesquisas; Goncalo Moniz, Salvador, BA, Brasil.

Abstract: To determine the genomic polymorphism and biological properties present in HIV-1 Brazilian isolates, we analyzed five viral isolates obtained from patients residing in Rio de Janeiro (P1 and P5), Sao Paulo (P3) and Bahia (P2 and P4) states. For each viral isolate in vitro characteristics such as replication rate, syncytium-inducing capacity and cell death were observed in lymphoblastoid (H9, CEM and peripheral blood mononuclear cells) as well as monocytoid (U937) cells. In addition, the evaluation of the restriction fragment length polymorphism of these isolates was also performed using a panel of endonucleases such as Hind III, Bgl II, Sac I, Pst I, Kpn I and Eco RI. One of the isolates (P1), showed the highest phenotypic and genotypic divergence, when compared to others. The results found suggest a HIV heterogeneity in Brazil similar to that already described in other regions of the world.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Brazil DNA, Viral/*ANALYSIS Human HIV-1/*GENETICS/PATHOGENICITY Male Polymorphism (Genetics) Polymorphism, Restriction Fragment Length Restriction Mapping Support, Non-U.S. Gov't *Variation (Genetics) Virulence JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/microbiologybrazildna,viral/KWDanalysishumanhiv-1/KWDgenetics/pathogenicitymalepolymorphism(genetics)polymorphism,restrictionfragmentlengthrestrictionmappingsupport,non-uKWDsKWDgov'tKWDvariation(genetics)virulencejournalarticle
931230
M93C0766

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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