Karyotypic abnormalities in hyperplastic lymph node biopsies; prognosis may depend on immunologic status (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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Karyotypic abnormalities in hyperplastic lymph node biopsies; prognosis may depend on immunologic status (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A1256 1993. Unique Identifier : AIDSLINE ICDB/93692226
Wachtel M; Parsa NZ; Offit K; Filippa D; Chaganti RS; Memorial Sloan-Kettering Cancer Center, New York, NY 10021

Abstract: Over a 7-yr period, 71 biopsies revealing lymphoid hyperplasia (or atypical hyperplasia) were subjected to karyotypic analysis. An additional 8 cases with miscellaneous nondiagnostic histologies were also included. In 32 cases, there was history of immune compromise; 27 were HIV positive and 5 had autoimmune disorders. Of these, 7 demonstrated clonal or nonclonal karyotypic abnormalities. No patient developed hematologic cancer at 30.1 mo median follow-up. Of 47 immunocompetent patients, 5 demonstrated clonal or nonclonal karyotypic abnormalities. Of these, 2 developed lymphoma, with a median follow-up of 39.6 mo for the group. In comparison to cases with normal karyotypes (42 immunocompetent and 25 immunocompromised), a negative prognostic significance for karyotypic abnormalities was demonstrated only in the immunocompromised group. These results suggest the importance of a clinical history of immune compromise in the interpretation of cytogenetic analysis of hyperplastic lymph nodes.
Keywords: Autoimmune Diseases/GENETICS/PATHOLOGY Cell Transformation, Neoplastic/GENETICS/PATHOLOGY Chromosome Aberrations/*GENETICS Follow-Up Studies Human Hyperplasia HIV Seropositivity/GENETICS/PATHOLOGY *Karyotyping Lymph Nodes/*PATHOLOGY Lymphoma/*GENETICS/PATHOLOGY Precancerous Conditions/*GENETICS/PATHOLOGY ABSTRACTKWDautoimmunediseases/genetics/pathologycelltransformation,neoplastic/genetics/pathologychromosomeaberrations/KWDgeneticsfollow-upstudieshumanhyperplasiahivseropositivity/genetics/pathologyKWDkaryotypinglymphnodes/KWDpathologylymphoma/KWDgenetics/pathologyprecancerousconditions/KWDgenetics/pathologyabstract
930830
M9380834

Copyright © 1993 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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