Cell death and DNA fragmentation induced by novel compounds merocil and merodantoin (Meeting abstract).

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

Cell death and DNA fragmentation induced by novel compounds merocil and merodantoin (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 34:A2196 1993. Unique Identifier : AIDSLINE ICDB/93693150
Gulliya KS; Franck B; Schneider U; Sharma RK; Arnold L; Matthews JL; Baylor Res. Inst., Dallas, TX 75226

Abstract: Preactivation of photoactive compounds results in the formation of heretofore unknown products. These products were found to be effective against tumor cells and viruses including HIV-1 (Gulliya et al). Recently, three heterocyclic products, meroxazol, merocil, and merodantoin, were isolated and characterized. Only merocil and merodantoin were found to be effective in inhibiting the proliferation of certain tumor cells including lymphoma Daudi cells. Treatment of lymphoma cells with these compounds resulted in a rapid decline in macromolecular synthesis. DNA fragmentation, characteristic of programmed cell death, was observed as early as 30 min following drug treatment. However, a rise in intracellular calcium did not precede DNA fragmentation, and a significant reduction in intracellular pH was not observed. These observations suggest that programmed cell death induced by merocil and merodantoin may be mediated via pathways other than those involving an early rise in intracellular calcium or a reduction in intracellular pH.

Keywords: Antineoplastic Agents/PHARMACOLOGY *Cell Death DNA, Neoplasm/*DRUG EFFECTS Heterocyclic Compounds/*PHARMACOLOGY/THERAPEUTIC USE Hydrogen-Ion Concentration Lymphoma/DRUG THERAPY/*PATHOLOGY Tumor Cells, Cultured ABSTRACT
930830
M9380830

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