[Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in Sao Paulo, Brazil] NLM AIDSLINE Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

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[Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in Sao Paulo, Brazil]

Rev Inst Med Trop Sao Paulo. 1991 Nov-Dec;33(6):485-90. Unique Identifier : AIDSLINE MED/93255362
Calvo B; Fischman O; Castelo Filho A; Reis Filho J; Del Bianco R; Barbosa RM; Zaror L; Disc. Biologia Celular y Enfermedades Infecciosas y Parasitarias; de Escola Paulista de Medicina, Sao Paulo, Brasil.

Abstract: Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/MORTALITY Adolescence Adult Antigens, Bacterial/*ISOLATION & PURIF Brain Diseases/*IMMUNOLOGY/MORTALITY Brazil Cryptococcosis/*IMMUNOLOGY/MORTALITY Cryptococcus neoformans/*IMMUNOLOGY English Abstract Female Human Male Middle Age Polysaccharides/*IMMUNOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDimmunology/mortalityadolescenceadultantigens,bacterial/KWDisolation&purifbraindiseases/KWDimmunology/mortalitybrazilcryptococcosis/KWDimmunology/mortalitycryptococcusneoformans/KWDimmunologyenglishabstractfemalehumanmalemiddleagepolysaccharides/KWDimmunologyjournalarticle
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M9380821

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