[Infection by cytomegalovirus in patients with acquired immunodeficiency syndrome (AIDS): clinical, virological, and histopathological correlations]

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

[Infection by cytomegalovirus in patients with acquired immunodeficiency syndrome (AIDS): clinical, virological, and histopathological correlations]

Rev Inst Med Trop Sao Paulo. 1991 Jul-Aug;33(4):243-50. Unique Identifier : AIDSLINE MED/93255325
Turchi MD; Pannuti CS; Sumita LM; Vilas Boas LS; Weinberg A; Stavale JN; Borges AF; Collarine DC; dos Santos HV; Kitadai SS; Departamento de Doencas Infecto-parasitarias, Escola Paulista; de Medicina (EPM), Bolsista da FAPESP, Brasil.

Abstract: Between April 1986 and June 1987, 50 patients meeting the CDC criteria for AIDS were studied for serological and virological evidence of CMV infection. Attempts for virus isolation from peripheral blood, urine and saliva were performed in cell culture lines of human foreskin fibroblasts and CMV specific IgG and IgM were assayed by IFI and IgG by ELISA. A total of 121 blood, 119 urine and 96 saliva samples were collected. During the study period viremia was noted at least once in 12.5%, viruria in 23.2%, and excretion in saliva in 21.9%. When admitted in the study, 20% (10/50) of the patients had anti-CMV IgM antibodies and 100% (50/50) of them had IgG anti-CMV antibodies (IFI). Five of the 40 patients IgM negative at admission presented anti-CMV IgM antibodies during the study, suggesting CMV reactivation or reinfection. Active CMV infection based on virus isolation and/or IgM positivity was demonstrated in 60% of the patients. Histopathological studies were performed in 24 patients. CMV was found in 50% of the autopsies, mainly in the digestive system, lungs and adrenals. There was no correlation between clinical, virological (serology and isolation) and histopathological diagnosis.

Keywords: Adult AIDS-Related Opportunistic Infections/BLOOD/DIAGNOSIS/ *EPIDEMIOLOGY/URINE Brazil/EPIDEMIOLOGY Comparative Study Cytomegalovirus/ISOLATION & PURIF Cytomegalovirus Infections/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY/URINE English Abstract Female Human Male Middle Age Prevalence Prospective Studies Saliva/MICROBIOLOGY JOURNAL ARTICLE
930830
M9380791

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