CONSTITUTIVE EXPRESSION OF ZINC FINGER TRANSCRIPTIONAL REGULATORY FACTORS BY HUMAN SOLID TUMOR CELL LINES (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


CONSTITUTIVE EXPRESSION OF ZINC FINGER TRANSCRIPTIONAL REGULATORY FACTORS BY HUMAN SOLID TUMOR CELL LINES (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 33:A2238 1992. Unique Identifier : AIDSLINE ICDB/92684789
Wright J; Takimoto C; Carbone D; Allegra C; Medicine and Navy-Med. Oncology Branches, NCI, Bethesda MD 20892

Abstract: Zinc finger genes 225 (EGR-1) and 592 (EGR-2) are rapidly and transiently expressed in cells transiting from G0 to G1. In contrast, T cells transformed by HTLV-I or HTLV-II constitutively express these genes suggesting that dysregulation of these factors plays a critical role in transformation. We investigated solid tumor cell lines, including 4 rhabdomyosarcomas, 5 colon cancer and 12 small cell (SCLC) and non-small cell cancers (NSCLC) of the lung, for constitutive expression of 225 and 592. All rhabdomyosarcoma cell lines and 3 colon cancer cell lines constitutively expressed 225. Approx 25% and 50% of SCLC and NSCLC cell lines, respectively, expressed 225 constitutively. All extrapulmonary SCLC tumors were positive. No correlation between SCLC morphology and expression was noted. Coexpression of 225 and 592 was seen in one NSCLC cell line but no other cells expressed 592. These studies support a role for 225 in malignant transformation of solid tumors, and suggest that alternative pathways for constitutive activation of these genes exist in the absence of retrovirus transformation.
Keywords: Carcinoma, Non-Small-Cell Lung/GENETICS Carcinoma, Small Cell/GENETICS Cell Transformation, Viral Colonic Neoplasms/GENETICS Human HTLV-I HTLV-II Lung Neoplasms/GENETICS Rhabdomyosarcoma/GENETICS *Transcription, Genetic Tumor Cells, Cultured *Zinc Fingers ABSTRACTKWDcarcinoma,non-small-celllung/geneticscarcinoma,smallcell/geneticscelltransformation,viralcolonicneoplasms/geneticshumanhtlv-ihtlv-iilungneoplasms/geneticsrhabdomyosarcoma/geneticsKWDtranscription,genetictumorcells,culturedKWDzincfingersabstract
920930
M9290909

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .