T lymphocyte subsets in chronic AgHBe positive hepatitis and the effects of prednisone therapy. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


T lymphocyte subsets in chronic AgHBe positive hepatitis and the effects of prednisone therapy.

Rev Hosp Clin Fac Med Sao Paulo. 1990 Nov-Dec;45(6):244-7. Unique Identifier : AIDSLINE MED/92302730
Mattar R; da Fonseca LE; da Silva LC; Department of Gastroenterology, Hospital das Clinicas de Sao; Paulo.

Abstract: T lymphocyte subsets were studied in 18 patients with chronic AgHBe positive hepatitis. The study was carried out before, during and after a ten week course of prednisone therapy. There was no statistically significant difference during and after prednisone therapy in patients with hepatitis as to the total lymphocyte number and T lymphocyte subsets. The CD4/CD8 ratio was significantly decreased when compared with that of the normal controls, as the result of a reduction in CD4 T lymphocyte population before the beginning of the therapy. The patients did not respond to prednisone therapy.
Keywords: *CD4-CD8 Ratio Double-Blind Method Female Hepatitis B/*DRUG THERAPY/IMMUNOLOGY Hepatitis B e Antigens/ANALYSIS Human Male Prednisone/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE *T-Lymphocyte Subsets CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIALKWDcd4-cd8ratiodouble-blindmethodfemalehepatitisb/KWDdrugtherapy/immunologyhepatitisbeantigens/analysishumanmaleprednisone/administration&dosage/KWDtherapeuticuseKWDt-lymphocytesubsetsclinicaltrialjournalarticlerandomizedcontrolledtrial
920930
M9290898

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .