Neurologic complications of HIV infection in children.

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Neurologic complications of HIV infection in children.

Pediatr Neurosurg. 1991-92;17(2):104-12. Unique Identifier : AIDSLINE MED/92273496
Civitello LA; Department of Neurology and Pediatrics, Children's National; Medical Center, George Washington University, Washington, D.C.

Abstract: Neurologic abnormalities occur frequently in children with symptomatic HIV-1 infection (class P2) and include cognitive, language and motor deficits, as well as acquired microcephaly. Neurologic abnormalities can be seen as early as the first 3 months of age and can precede signs of immune deficiency and systemic illness. Hypotonia, delayed or poor head control and decreased vocalizations are some of the early neurologic manifestations of HIV-1 infection. In the majority of cases CNS impairment appears to be related to HIV-1 brain infection although at this time the exact timing of CNS invasion by the virus and the pathogenesis of CNS dysfunction are unknown. Treatment with antiretroviral agents can at least temporarily improve neurologic functioning in some children with HIV-1-related encephalopathy.

Keywords: AIDS Dementia Complex/*DIAGNOSIS/PATHOLOGY Brain/PATHOLOGY Child Human HIV Infections/*DIAGNOSIS/PATHOLOGY *HIV-1 Infant Nervous System Diseases/*DIAGNOSIS/PATHOLOGY *Neurologic Examination Spinal Cord/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
920930
M9290894

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