Tissue level lymphocyte subpopulations in donovanosis. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Tissue level lymphocyte subpopulations in donovanosis.

Int J Dermatol. 1991 Dec;30(12):857-9. Unique Identifier : AIDSLINE MED/92275879
Sehgal VN; Gupta MM; Jain VK; Department of Dermatology and Venereology, Maulana Azad Medical; College, New Delhi, India.

Abstract: Total T-, B-, T4-, and T8-lymphocyte populations were estimated in tissue sections of ulcers from 22 donovanosis patients, comprising 17 ulcerogranulomatous, four hypertrophic, and one sclerotic variants, using monoclonal antibodies and immunohistochemical technique (PAP). T- and B-lymphocytic infiltrations in the tissues were almost identical, without any significant difference in ulcerogranulomatous and hypertrophic variants. The T4:T8 ratio in ulcerogranulomatous variants, however, was 1.41, which was significantly higher than that of hypertrophic variants (1.28), indicating a greater cell-mediated immune response in the former than in the latter. This is substantiated by the documentation of a paucity of Donovan bodies, both in the tissue smear and slow (overnight) Giemsa-stained tissue sections, in the ulcerogranulomatous variant.
Keywords: Aged B-Lymphocytes CD4-CD8 Ratio Granuloma Inguinale/*PATHOLOGY Human Hypertrophy Leukocyte Count *Lymphocyte Subsets/IMMUNOLOGY Middle Age Skin Ulcer/PATHOLOGY T-Lymphocytes JOURNAL ARTICLEKWDagedb-lymphocytescd4-cd8ratiogranulomainguinale/KWDpathologyhumanhypertrophyleukocytecountKWDlymphocytesubsets/immunologymiddleageskinulcer/pathologyt-lymphocytesjournalarticle
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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