CHARACTERIZATION OF A KAPOSI'S SARCOMA CELL LINE THAT INDUCES ANGIOBLASTIC TUMORS IN NUDE MICE AND DEMONSTRATES CHARACTERISTICS OF ANGIOGENESIS (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

CHARACTERIZATION OF A KAPOSI'S SARCOMA CELL LINE THAT INDUCES ANGIOBLASTIC TUMORS IN NUDE MICE AND DEMONSTRATES CHARACTERISTICS OF ANGIOGENESIS (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 33:A2178 1992. Unique Identifier : AIDSLINE ICDB/92684725
Werner A; Herndier B; Levy JA; Cancer Res. Inst., Dept. of Medicine, Univ. of California Sch. of; Medicine, San Francisco, CA 94143-0128

Abstract: A cell line was derived from a biopsy specimen of Kaposi's sarcoma (KS) in an HIV-negative individual. It was found to induce KS-like tumors in nude animals (Siegal et al, Cancer 65:492, 1990). Further studies indicate that the tumors formed had several characteristics of KS or angiosarcomas. The karyotype of the cells shows human origin with a phenotype different from that of other known human tumor cell lines. Cells grown in culture have an 'epithelial' morphology with some differential features. Immunohistochemical staining demonstrates the presence of cytoplasmic Factor VIII, a protein synthesized by endothelial cells. Markers for macrophages and other leukocytes are negative. These results define the first human KS cell line to induce malignant tumors in animals and maintain the characteristics of an angiogenic sarcoma. Results of other studies, including electron microscopy to detect an etiologic agent and determine mechanisms for tumorigenesis, are presented.

Keywords: Animal Factor VIII/METABOLISM Hemangiosarcoma/PATHOLOGY Immunohistochemistry Karyotyping Mice Mice, Nude *Neovascularization, Pathologic Phenotype Sarcoma, Kaposi's/*GENETICS/METABOLISM Tumor Cells, Cultured ABSTRACT
921030
M92A1028

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