Single photon emission computed tomography (SPECT) with [123I]IMP in the differential diagnosis of psychiatric disorders. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Single photon emission computed tomography (SPECT) with [123I]IMP in the differential diagnosis of psychiatric disorders.

J Neuropsychiatry Clin Neurosci. 1989 Spring;1(2):145-53. Unique Identifier : AIDSLINE MED/92330314
O'Connell RA; Van Heertum RL; Billick SB; Holt AR; Gonzalez A; Notardonato H; Luck D; King LN; Department of Psychiatry, St. Vincent's Hospital and Medical; Center, New York, NY 10011.

Abstract: Single photon emission computed tomography (SPECT) with [123I]N-isopropyl iodoamphetamine--[123I]IMP--was used to study regional cerebral blood flow (rCBF) in 94 psychiatric patients and six controls. Patients with dementias had distinct brain-image patterns, consistent with the expected neuropathology. Major depressives had decreased cortical and subcortical rCBF. Increased caudate rCBF was observed in schizophrenics and other psychoses with positive symptoms. SPECT is a practical method of functional brain imaging with potential in the differential diagnosis of neuropsychiatric disorders. Further studies are needed to assess the effect of other variables on brain-image patterns.
Keywords: Adult Alzheimer's Disease/PSYCHOLOGY/RADIONUCLIDE IMAGING Amphetamines/DIAGNOSTIC USE AIDS Dementia Complex/PSYCHOLOGY/RADIONUCLIDE IMAGING Bipolar Disorder/PSYCHOLOGY/RADIONUCLIDE IMAGING Brain/*BLOOD SUPPLY Brain Mapping Caudate Nucleus/BLOOD SUPPLY Cerebral Cortex/BLOOD SUPPLY Depressive Disorder/PSYCHOLOGY/RADIONUCLIDE IMAGING Diagnosis, Differential Female Human Iodine Radioisotopes/DIAGNOSTIC USE Male Middle Age Organic Mental Disorders, Psychotic/PSYCHOLOGY/*RADIONUCLIDE IMAGING Psychotic Disorders/PSYCHOLOGY/RADIONUCLIDE IMAGING Regional Blood Flow/PHYSIOLOGY Schizophrenia/RADIONUCLIDE IMAGING Schizophrenic Psychology *Tomography, Emission-Computed, Single-Photon JOURNAL ARTICLEKWDadultalzheimer'sdisease/psychology/radionuclideimagingamphetamines/diagnosticuseaidsdementiacomplex/psychology/radionuclideimagingbipolardisorder/psychology/radionuclideimagingbrain/
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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