Clinical manifestations and treatment of HIV related non-Hodgkin lymphoma. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Clinical manifestations and treatment of HIV related non-Hodgkin lymphoma.

Cancer Surv. 1991;10:121-33. Unique Identifier : AIDSLINE MED/92331040
Northfelt DW; Kaplan LD; Division of AIDS Activities/Oncology, University of California,; San Francisco.

Abstract: Non-Hodgkin lymphoma developing in patients with HIV infection fulfills diagnostic criteria for AIDS. Clinical manifestations of AIDS-NHL are similar to those of malignant lymphoma arising in other acquired and congenital immunodeficiency states. AIDS related NHLs therefore consist primarily of tumours with B cell phenotype, intermediate or high grade histological subtype and rapid clinical progression with a high frequency of unusual extranodal involvement. Treatment of AIDS-NHL has been much less rewarding than treatment of lymphoma in non-HIV infected individuals. Complete response rates are lower than the corresponding rates seen in the non-HIV infected population, and responses that do occur tend to be of short duration. Improvements in treatment for AIDS-NHL will require the use of new therapies, designed to cause less myelosuppression, in conjunction with aggressive efforts to prevent opportunistic infections.
Keywords: Antineoplastic Agents, Combined/*THERAPEUTIC USE Human HIV Infections/COMPLICATIONS Lymphoma, AIDS-Related/DIAGNOSIS/*DRUG THERAPY/ETIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDantineoplasticagents,combined/KWDtherapeuticusehumanhivinfections/complicationslymphoma,aids-related/diagnosis/KWDdrugtherapy/etiologyjournalarticlereviewreview,tutorial
921030
M92A0983

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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