DEGREE OF IMMUNODEFICIENCY AT DIAGNOSIS OF AIDS-ASSOCIATED NON-HODGKIN'S LYMPHOMA (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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DEGREE OF IMMUNODEFICIENCY AT DIAGNOSIS OF AIDS-ASSOCIATED NON-HODGKIN'S LYMPHOMA (MEETING ABSTRACT)

Proc Annu Meet Am Soc Clin Oncol; 11:A7 1992. Unique Identifier : AIDSLINE ICDB/92680738
Northfelt DW; Volberding PA; Kaplan LD; Univ. of California, San Francisco, CA

Abstract: In clinical practice, the CD4+ T-lymphocyte count (CD4) is used as a measure of the degree of immunodeficiency caused by human immunodeficiency virus (HIV). Clinical events in HIV infection have been correlated with CD4; for example, Pneumocystis carinii pneumonia usually occurs when CD4 is less than 200 cells/mm3. Recently, it has been suggested that the risk of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) is greater when CD4 is less than 50. To examine the degree of immunodeficiency at diagnosis of AIDS-NHL (non-CNS) in a well-characterized cohort, we reviewed CD4 at AIDS-NHL diagnosis in 85 consecutive patients seen from 1/1/89-12/1/91. Results: CD4 at diagnosis were available for 80 of 85 patients. Data are presented in a table. Conclusion: The degree of immunodeficiency at diagnosis of AIDS-NHL, as assessed by CD4, varies over a wide range. Our data suggest that CD4 less than 50 is not a useful marker for the development of AIDS-NHL.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/*IMMUNOLOGY Antigens, CD4/*ANALYSIS Biological Markers Cohort Studies Comparative Study Human HIV Infections/*COMPLICATIONS/*IMMUNOLOGY Lymphoma, Non-Hodgkin's/*ETIOLOGY/*IMMUNOLOGY Prognosis T-Lymphocyte Subsets/*IMMUNOLOGY ABSTRACT

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/KWDimmunologyantigens,cd4/KWDanalysisbiologicalmarkerscohortstudiescomparativestudyhumanhivinfections/KWDcomplications/KWDimmunologylymphoma,non-hodgkin's/KWDetiology/KWDimmunologyprognosist-lymphocytesubsets/KWDimmunologyabstract
921130
M92B0901

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