THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF PODOPHYLLOTOXIN AND TAXOL ANALOGS NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF PODOPHYLLOTOXIN AND TAXOL ANALOGS

Diss Abstr Int [B]; 52(4):2031 1991. Unique Identifier : AIDSLINE ICDB/92679123
Do HD; Northern Illinois Univ.

Abstract: The synthesis and biological evaluation of analogs of two antimitotic natural products were undertaken. Application of a novel manganese(III) acetate oxidation process provided the key step in the synthesis of podophyllotoxin congeners. The syntheses of several A and AB-ring taxol analogs were also accomplished. A tubulin turbidimetric assay was used to evaluate the bioactivity of the synthetic podophyllotoxin and taxol analogs. The brine shrimp toxicity test, platelet-activating factor binding assay, anti-Rhino and anti-Herpes viral assays of the podophyllotoxin intermediates are also summarized. The National Cancer Institute's anticancer and anti-HIV screening results of the podophyllotoxin intermediates are included. X-ray structures and 2-D NMR spectra of pertinent intermediates and products are reported. (Full text available from University Microfilms International, Ann Arbor, MI, as Order No. AAD91-27664).
Keywords: Alkaloids/*METABOLISM Antineoplastic Agents/*METABOLISM Artemia Biological Assay Herpesviridae Nephelometry and Turbidimetry Platelet Activating Factor/METABOLISM Podophyllotoxin/ANALOGS & DERIVATIVES/*METABOLISM Tubulin/DIAGNOSTIC USE THESIS

KWDalkaloids/KWDmetabolismantineoplasticagents/KWDmetabolismartemiabiologicalassayherpesviridaenephelometryandturbidimetryplateletactivatingfactor/metabolismpodophyllotoxin/analogs&derivatives/KWDmetabolismtubulin/diagnosticusethesis
920530
M9250960

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .