INADEQUATE T-CELL HELP AND INCREASED CONCENTRATION OF IL-2 RECEPTOR IN LUNG CANCER (LC) (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

INADEQUATE T-CELL HELP AND INCREASED CONCENTRATION OF IL-2 RECEPTOR IN LUNG CANCER (LC) (MEETING ABSTRACT)

Chest; 100(2, Suppl):40S 1991. Unique Identifier : AIDSLINE ICDB/92679228
Marino P; Fruttero A; Preatoni A; Bossi B; Ferrigno D; Buccheri GF; Dipartimento di Medicina dell'Universita, Ospedale S. Paolo,; Milan, Italy

Abstract: Previously, we showed increased serum levels of the IL-2 receptor (sIL-2r) in patients (pts) with lung cancer (Br J Cancer, 1990). The goal of the present study was to evaluate CD expression on resting and activated T cells and to seek a relationship between sIL-2r and T-cell phenotype. We have studied sIL-2r concentrations in serum and in supernatants of phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMC) derived from 14 pts with untreated LC at various stages of disease and with no overlapping infection. The T-cell phenotype of PBMC of the same pts was also studied. As control, 21 subjects were investigated in parallel. Data are reported as percentages. Significantly lower CD4 (36% vs 49; p less than 0.01), CD3 (62% vs 75; p less than 0.001) and CD4/CD8 ratio (p less than 0.05) as well as increased CD25 (TAC antigen; 10.5% vs 3.9; p less than 0.001) was found in unstimulated T-cell subpopulation. No significant difference in suppressor T cell was found. Metastatic pts compared with nonmetastatic pts showed an increase in the CD3 T-cell subtype (p less than 0.05). A significant difference was found between nonstimulated CD4 and stimulated CD4 (p less than 0.05), as well as within CD25 (p less than 0.001). Correlation was good for sIL-2r and the nonstimulated expression of CD25 (p less than 0.01). Relationship between CD25 and the histological type of the disease was also found (p less than 0.01). It can be concluded from the results of these studies that quantitative abnormalities of helper T cells or interleukin-2 receptor coexist in pts with lung cancer.

Keywords: Antigens, CD4/ANALYSIS Antigens, Differentiation, T-Lymphocyte/ANALYSIS CD4-CD8 Ratio Human Leukocytes, Mononuclear/IMMUNOLOGY Lung Neoplasms/*IMMUNOLOGY Receptors, Antigen, T-Cell/ANALYSIS Receptors, Interleukin-2/*ANALYSIS ABSTRACT

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