LYMPHOCYTE SUBSETS IN PLEURAL EFFUSIONS (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

LYMPHOCYTE SUBSETS IN PLEURAL EFFUSIONS (MEETING ABSTRACT)

Chest; 100(2, Suppl):41S 1991. Unique Identifier : AIDSLINE ICDB/92679233
Chiner E; Larramendi CH; Calpe J; Munoz J; Chest and Immunology Sections, Hosp. de la Vila Joiosa-Benidorm,; Spain

Abstract: Differences between pleural fluid and blood lymphocyte subsets have been scarcely studied. We have evaluated a group of 19 patients with pleural effusion (PE) of diverse etiology (10 transudates [Tr] and 9 exudates [Ex]) according to the Light's criteria. Quantitation of lymphocyte subsets was performed by cell flow cytometry in PE and blood (B) samples simultaneously. Results are presented in a table. In all pleural fluids (Tr+Ex), an increase in T4 and T4/T8 ratio was observed compared with B (p less than 0.01). Similar changes existed in Tr but T8 were lower in Pe than in B (p less than 0.05). However, no differences were observed in Ex between PE and B; T4 were slightly higher in PE than in B (p less than 0.01). Between Tr and Ex there only appeared differences for T4 in B (p less than 0.05). The only difference in PE was a T4/T8 ratio slightly higher for Tr (p less than 0.1). Our results show an increase of T4 in PE compared to blood irrespective of the etiology of PE but more pronounced for transudates. Lymphocyte subsets in PE are similar to those in B for exudates, but the same is not true for transudates that show a higher T4/T8 ratio.

Keywords: CD4-CD8 Ratio *CD4-Positive T-Lymphocytes Human Pleural Effusion, Malignant/*IMMUNOLOGY/PATHOLOGY *T-Lymphocytes, Suppressor-Effector ABSTRACT

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