Viruses in the pathogenesis of systemic lupus erythematosus. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Viruses in the pathogenesis of systemic lupus erythematosus.

In Vivo. 1988 Jan-Feb;2(1):15-8. Unique Identifier : AIDSLINE MED/92135548
Phillips PE; Division of Clinical Immunology, State University of New York; Health Science Center, Syracuse 13210.

Abstract: In spite of the lack of firm evidence implicating infectious agents, it is still likely that SLE requires an initiating event, probably environmental, and possibly infectious. In the setting of genetically determined perturbations of the immune system, an infectious trigger could be a trivial event clinically, and could be different in different patients. Once triggered, the immunologic abnormalities might be self-perpetuating so that the persistent infection and foreign antigens as found in hepatitis B vasculitis, might not be needed in SLE. Current evidence has not firmly implicated any specific microbial agents, but on a theoretical basis, the human retroviruses are particularly attractive candidates.
Keywords: Acquired Immunodeficiency Syndrome/MICROBIOLOGY Human HTLV-BLV Infections/MICROBIOLOGY Lupus Erythematosus, Systemic/ETIOLOGY/*MICROBIOLOGY Retroviridae/*PATHOGENICITY Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDacquiredimmunodeficiencysyndrome/microbiologyhumanhtlv-blvinfections/microbiologylupuserythematosus,systemic/etiology/KWDmicrobiologyretroviridae/KWDpathogenicitysupport,non-uKWDsKWDgov'tjournalarticlereviewreview,tutorial
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M9250945

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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