Alpha-oligonucleotides: a unique class of modified chimeric nucleic acids. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Alpha-oligonucleotides: a unique class of modified chimeric nucleic acids.

Anticancer Drug Des. 1991 Dec;6(6):521-9. Unique Identifier : AIDSLINE MED/92126175
Morvan F; Rayner B; Imbach JL; Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Universite; Montpellier II, France.

Abstract: alpha-Anomeric oligonucleotides are resistant to nucleases and display parallel hybridization with complementary DNA and RNA sequences. Although alpha-DNA/beta-RNA duplexes are not substrates for RNases H, alpha-oligos are able to inhibit translation through a RNase H independent mechanism. alpha-Oligos and their alpha-phosphorothioate analogs (12 mer) targeted against the splice acceptor site of the HIV-TAT gene were potent inhibitors of de novo HIV infection. Furthermore alpha-phosphorothioate and dithioate homo-oligomers exhibit an in vitro, nonsequence-specific, inhibitory effect on HIV reverse transcriptase.
Keywords: Base Sequence Drug Design Molecular Sequence Data Molecular Structure Nucleic Acids/*CHEMISTRY Oligonucleotides/CHEMISTRY/*CHEMICAL SYNTHESIS Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDbasesequencedrugdesignmolecularsequencedatamolecularstructurenucleicacids/KWDchemistryoligonucleotides/chemistry/KWDchemicalsynthesissupport,non-uKWDsKWDgov'tjournalarticlereviewreview,tutorial
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M9250934

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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