The use of intermingled autograft and parental allograft skin in the treatment of major burns in children. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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The use of intermingled autograft and parental allograft skin in the treatment of major burns in children.

Br J Plast Surg. 1991 Nov-Dec;44(8):608-11. Unique Identifier : AIDSLINE MED/92127290
Phipps AR; Clarke JA; South West Thames Regional Burns Unit, Queen Mary's University; Hospital, London.

Abstract: Large burns continue to pose the problem of providing sufficient autologous skin cover. The experience of this unit using cultured keratinocytes as a substitute for split-skin grafts has been disappointing; at the same time, we have been obliged to abandon human allograft skin from cadavers and other patients because of the possibility of infection with HIV. Our favoured method for resurfacing large-area burns in children is to use widely meshed autologous skin overlaid with meshed allograft from a parent (to minimise the risk of HIV transmission). We report our experience using this technique in 10 children. The fate of the intermingled grafts has been followed clinically, and in some cases histologically and by Y-chromosome identification. There has generally been long-term persistence of the parental skin without rejection, and allograft dermis appears to contribute to the final cover. Evidence suggests, however, that cellular elements of the parental skin do not survive.
Keywords: Burns/*SURGERY Child Child, Preschool Female Graft Survival Human Infant Male Postoperative Complications/PREVENTION & CONTROL *Skin Transplantation Transplantation, Autologous Transplantation, Homologous JOURNAL ARTICLE

KWDburns/KWDsurgerychildchild,preschoolfemalegraftsurvivalhumaninfantmalepostoperativecomplications/prevention&controlKWDskintransplantationtransplantation,autologoustransplantation,homologousjournalarticle
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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