Mania in AIDS: clinical significance and theoretical considerations. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Mania in AIDS: clinical significance and theoretical considerations.

Int J Psychiatry Med. 1991;21(4):383-91. Unique Identifier : AIDSLINE MED/92129059
el-Mallakh RS; National Institute of Mental Health, Neuropsychiatric Research; Hospital, Washington, D.C.

Abstract: Cases of mania associated with acquired immune deficiency syndrome (AIDS) are reviewed in an attempt to elucidate patterns that may be helpful in guiding treatment, determining prognosis, and understanding pathophysiology. Fourteen well-described cases in the English language literature were critically reviewed. Data was collected regarding chronological appearance of signs and symptoms, specific psychiatric symptoms, associated neurologic and cognitive function, objective testing of brain structure and function, and outcome. When mania or hypomania occur in the setting of a human immunodeficiency virus (HIV) infection, it frequently occurs once and does not recur. AIDS-associated manic states are adequately responsive to available antimanic agents, however, AIDS patients may be more prone to deleterious side effects. Although mania or hypomania may be the presenting complaints that lead to the discovery of human immunodeficiency virus (HIV) seropositive status, mania tends to occur in people exhibiting signs of immunodeficiency as is exemplified, in the sample, by death occurring within six months of the psychiatric presentation in nearly a quarter of the patients. It is hypothesized that AIDS-related mania and agitated psychosis may be related to increased intracellular free calcium.
Keywords: AIDS Dementia Complex/*DIAGNOSIS Calcium Channel Blockers/THERAPEUTIC USE Electroencephalography Female Human Manic Disorder/*DIAGNOSIS Tomography, X-Ray Computed Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE

KWDaidsdementiacomplex/KWDdiagnosiscalciumchannelblockers/therapeuticuseelectroencephalographyfemalehumanmanicdisorder/KWDdiagnosistomography,x-raycomputedzidovudine/therapeuticusejournalarticle
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M9250912

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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