Cognitive-behavioral stress management intervention buffers distress responses and immunologic changes following notification of HIV-1 seropositivity. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Cognitive-behavioral stress management intervention buffers distress responses and immunologic changes following notification of HIV-1 seropositivity.

J Consult Clin Psychol. 1991 Dec;59(6):906-15. Unique Identifier : AIDSLINE MED/92129722
Antoni MH; Baggett L; Ironson G; LaPerriere A; August S; Klimas N; Schneiderman N; Fletcher MA; Department of Psychology, University of Miami, Coral Gables,; Florida 33124.

Abstract: Forty-seven asymptomatic, healthy gay men were randomly assigned to a cognitive-behavioral stress management (CBSM) condition or an assessment-only control group 5 weeks before being notified of their HIV-1 antibody status. Seventy-two hours before and 1 week after serostatus notification, blood samples and psychometric data were collected. Control subjects showed significant increases in depression, but only slight decrements in mitogen responsivity and lymphocyte cell counts pre- to postnotification of seropositivity. Seropositive CBSM Ss did not show significant pre-post changes in depression, but did reveal significant increases in helper-inducer (CD4) and natural killer (CD56) cell counts as well as a slight increment in proliferative responses to phytohemagglutinin (PHA). Individual difference analyses suggest that the psychological buffering and immunomodulating effects of the CBSM manipulation may be attributable, in part, to relaxation skills learned and practiced or to a general willingness to comply with the intervention guidelines.
Keywords: *Adaptation, Psychological/PHYSIOLOGY Adult AIDS Serodiagnosis/*PSYCHOLOGY Cognitive Therapy/*METHODS CD4-CD8 Ratio Health Behavior Homosexuality/PSYCHOLOGY Human HIV Seropositivity/*IMMUNOLOGY/*PSYCHOLOGY *HIV-1 Lymphocyte Transformation/IMMUNOLOGY Male *Sick Role Support, U.S. Gov't, P.H.S. CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL

KWDadaptation,psychological/physiologyadultaidsserodiagnosis/KWDpsychologycognitivetherapy/KWDmethodscd4-cd8ratiohealthbehaviorhomosexuality/psychologyhumanhivseropositivity/KWDimmunology/KWDpsychologyKWDhiv-1lymphocytetransformation/immunologymaleKWDsickrolesupport,uKWDsKWDgov't,pKWDhKWDsKWDclinicaltrialjournalarticlerandomizedcontrolledtrial
920530
M9250904

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1992. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .