Detection of anti-HIV antibodies in immunoglobulin preparations: the significance of antibodies to the HIV-envelope. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Detection of anti-HIV antibodies in immunoglobulin preparations: the significance of antibodies to the HIV-envelope.

Biologicals. 1991 Jul;19(3):197-202. Unique Identifier : AIDSLINE MED/92062366
Gentili G; Wirz M; Puccinelli M; Mele C; Collotti C; Vicari G; Laboratorio di Immunologia, Istituto Superiore di Sanita, Rome,; Italy.

Abstract: Four hundred and sixty-eight immunoglobulin preparations, produced between 1969 and 1989, were examined for anti-HIV antibodies by means of two competitive immunoenzymatic assays and the Western blot test. This study refers the results obtained by the three different methods. Such results show that the detection of anti-HIV antibodies in immunoglobulins may be performed on a routine basis using commercial kits intended for human sera. The meaning of the test and the role of antibodies against the HIV envelope proteins are emphasized.
Keywords: Blotting, Western/STATISTICS & NUMER DATA Comparative Study Drug Contamination False Positive Reactions Human HIV Antibodies/*ISOLATION & PURIF HIV Antigens Immunoenzyme Techniques/STATISTICS & NUMER DATA Immunoglobulins/*ISOLATION & PURIF Safety Sensitivity and Specificity Viral Envelope Proteins/*IMMUNOLOGY JOURNAL ARTICLE

KWDblotting,western/statistics&numerdatacomparativestudydrugcontaminationfalsepositivereactionshumanhivantibodies/KWDisolation&purifhivantigensimmunoenzymetechniques/statistics&numerdataimmunoglobulins/KWDisolation&purifsafetysensitivityandspecificityviralenvelopeproteins/KWDimmunologyjournalarticle
920330
M9230729

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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