INFECTIOUS COMPLICATIONS OF HODGKIN'S DISEASE

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

INFECTIOUS COMPLICATIONS OF HODGKIN'S DISEASE

Hodgkin's Disease: The Consequences of Survival. Lacher MJ and Redman JR, eds. Philadelphia, Lea and Febiger, p. 151-67, 1990.. Unique Identifier : AIDSLINE ICDB/92680214
Armstrong D; Minamoto GY; Cornell Univ. Medical Coll., New York, NY

Abstract: Recent improvements in combination chemotherapy and radiotherapy have significantly improved the long-term prognosis in Hodgkin's disease (HD), but the course of the disease often is complicated by infections that can be fatal, especially in patients (pts) in the later stage of disease and those considered cured. Infectious complications of Hodgkin's disease are reviewed, including regional infections (stomatopharyngitis; pneumonia; CNS; intra-abdominal, urinary tract, and skin infections, and sepsis); splenectomy; HD and AIDS; and prevention and treatment of infection in HD. Infectious complications generally are thought to be secondary to alterations in the immune system by the neoplasm itself and the therapy HD. The incidence of infections complicating HD is high and diagnosis often is difficult. Because fever associated with the neoplastic disease is common, therapy with immunosuppressive agents such as corticosteroids may mask signs and symptoms, and many microorganisms cause infections that are manifested atypically. Quantitative and functional defects in T lymphocytes make the host susceptible to a certain group of organisms, such as obligate or facultative intracellular parasites. Familiarity with the syndromes caused by these microorganisms and their treatment is essential to the management of pts with HD As the neoplastic disease progresses and treatment intensifies, pts become more susceptible to a wide variety of organisms, including those that depend on an appropriate neutrophil and antibody response. (79 Refs)

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Antibiotics/THERAPEUTIC USE B-Lymphocytes Central Nervous System Diseases/DRUG THERAPY/ETIOLOGY Cryptococcosis/ETIOLOGY Gastrointestinal Diseases/DRUG THERAPY/ETIOLOGY Hodgkin's Disease/*COMPLICATIONS/IMMUNOLOGY/THERAPY Human Listeria Infections/DRUG THERAPY/ETIOLOGY Mycoses/ETIOLOGY Pneumonia/ETIOLOGY Skin Diseases/ETIOLOGY Splenectomy T-Lymphocytes Toxoplasmosis/ETIOLOGY Urinary Tract Infections/ETIOLOGY Virus Diseases/ETIOLOGY MONOGRAPH
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M9261025

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