HTLV-1 (ATLV) AND T LYMPHOPROLIFERATIVE MALIGNANCIES (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

HTLV-1 (ATLV) AND T LYMPHOPROLIFERATIVE MALIGNANCIES (MEETING ABSTRACT)

Causes, Cures and Consequences of Lymphoproliferative Diseases--A Symposium to Honor George and Eva Klein. May 9-11, 1991, Omaha, NE, 1991.. Unique Identifier : AIDSLINE ICDB/92679932
Hinuma Y; Shionogi Inst. for Medical Science, Settsu-Shi, Osaka 566, Japan

Abstract: Retroviruses are involved in many naturally occurring neoplasms in various animal species. Their involvement in human neoplasias has been the subject of extensive research, but not until the early 1980s was definitive evidence obtained for causal association of a human retrovirus with a certain human disease. A type C retrovirus, named T-cell leukemia virus (HTLV-1), was isolated in 1980 from cases of sporadic, cutaneous T-cell lymphoma-leukemia in the USA (Poiesz et al, 1980, 1981). Independently, a retrovirus designated as adult T-cell leukemia virus (ATLV) was obtained in 1981 from cases of endemic adult T-cell leukemia (ATL) in Japan (Hinuma et al, 1981; Yoshida et al, 1982). Later, HTLV-1 and ATLV were identified to be the same virus (Watanabe et al 1984). There is now evidence that this retrovirus is etiologically related only to ATL and not to other malignancies, including T-cell lymphoid malignancies other than ATL. In 1985, two independent observations in Martinique and Japan noted the presence of antibodies to HTLV-I in the serum and cerebrospinal fluid of patients with chronic myelopathies of unknown origin (Gessain et al, 1985; Osame et al, 1986). These diseases in Martinique and Japan have been called tropical spastic paraparesis (TSP) and HTLV-1-associated myelopathy (HAM) respectively. After careful comparison of the two diseases, the TSP and HAM have been found to be the same disease which might be caused by infection with HTLV-I. Occurrence of both ATL and TSP/HAM in a single patient is rare.

Keywords: Human HTLV-I Antibodies/ANALYSIS HTLV-I Infections/*MICROBIOLOGY Leukemia, T-Cell/*MICROBIOLOGY Lymphoma, T-Cell, Cutaneous/*MICROBIOLOGY Paraparesis, Tropical Spastic/MICROBIOLOGY ABSTRACT
920630
M9261017

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