DETECTION OF NOVEL ETIOLOGICAL AGENTS AND HERPESVIRUSES (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

DETECTION OF NOVEL ETIOLOGICAL AGENTS AND HERPESVIRUSES (MEETING ABSTRACT)

Causes, Cures and Consequences of Lymphoproliferative Diseases--A Symposium to Honor George and Eva Klein. May 9-11, 1991, Omaha, NE, 1991.. Unique Identifier : AIDSLINE ICDB/92679935
Luka J; Univ. of Nebraska Medical Center, Omaha, Nebraska 68198

Abstract: Human herpesvirus-6 (HHV-6), human herpesvirus-7 (HHV-7) and B-lymphoma-associated virus (BLAV) are lymphotropic herpesviruses, which were discovered in the last few years. HHV-6, discovered in 1986 by Salahuddin et al, has been classified as a lymphotropic herpesvirus. The virus readily infects mitogen activated cord and peripheral blood cells in vitro. Certain T-cell lines can also be infected with the virus, however, nearly every strain of HHV-6 isolated so far requires a distinct type of T-cell line for replication. It has also been reported that HHV-6 may transform 3T3 fibroblast indicating that the virus may have oncogenic properties. In our laboratory, we successfully established several cell lines containing the latent HHV-6 genome by infection of established T-cell lines, peripheral and cord blood cells, in vitro with HHV-6. These cell lines express new T-cell markers on their surface which are not present on normal T-lymphocytes. HHV-7, another lymphotropic herpesvirus, was discovered in 1990 by Frenkel et al. This virus shares homologous DNA sequences with HHV-6 and the characterization of the virus is under progress. The newest human herpesvirus, BLAV, has been isolated from an EBV genome-negative Burkitt's lymphoma cell line. The virus is distinct from any known human herpesviruses based on DNA hybridization data and serological peripheral blood B cell in vitro. The possible role of HHV-6 and BLAV in AIDS and various lymphomas is discussed.

Keywords: Animal Biological Markers Blood Cells/MICROBIOLOGY Burkitt's Lymphoma/GENETICS Cells, Cultured DNA, Neoplasm/ANALYSIS Fetal Blood/MICROBIOLOGY Genome, Viral Herpesvirus 4, Human/GENETICS Herpesvirus 6, Human/GENETICS/*PHYSIOLOGY Herpesvirus 7, Human/*PHYSIOLOGY Mice Nucleic Acid Hybridization T-Lymphocytes/MICROBIOLOGY *Virus Replication 3T3 Cells ABSTRACT
920630
M9261016

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