OBSERVATION AND ANALYSIS OF THE DISTRIBUTION OF T CELL SUBSETS IN BREAST CANCER TISSUE (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

OBSERVATION AND ANALYSIS OF THE DISTRIBUTION OF T CELL SUBSETS IN BREAST CANCER TISSUE (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 33:A1807 1992. Unique Identifier : AIDSLINE ICDB/92684333
Luo CY; Zhan XE; Zhang XG; First Surgical Dept., Beijing Army General Hosp., Beijing, China

Abstract: In order to study the immunoreactive state in the tissue of breast cancer and its clinical significance, T cell subsets were observed with 3 monoclonal antibodies and ABC immunohistochemical technique in the tissues of 39 cases of breast cancer and 30 cases of breast benign diseases. The numbers of T cell subsets in cancer-nest mesenchyma were found more frequently than that in cancer-nest parenchyma, and OKT8+ cells obviously predominated over OKT4+ cells. OKT4+/OKT8+ ratios in cancer tissues were lower than that in benign tissues, whether in parenchyma or in mesenchyma. T cell subsets were sparse or even absent in cancer-nest parenchyma. These results indicate that the local immunity in breast cancer tissues is of low state, which may be one of reasons that tumor cells cannot be killed effectively.

Keywords: Antibodies, Monoclonal/IMMUNOLOGY Breast Neoplasms/*IMMUNOLOGY CD4-CD8 Ratio CD4-Positive T-Lymphocytes/IMMUNOLOGY Female Human Immunoenzyme Techniques T-Lymphocyte Subsets/*IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY ABSTRACT
920730
M9271105

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