Immune disturbances during major depression: upregulated expression of interleukin-2 receptors. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Immune disturbances during major depression: upregulated expression of interleukin-2 receptors.

Neuropsychobiology. 1990-91;24(3):115-20. Unique Identifier : AIDSLINE MED/92228147
Maes M; Bosmans E; Suy E; Vandervorst C; De Jonckheere C; Raus J; Psychiatric Center, St.-Jozef, Munsterbilzen, Belgium.

Abstract: We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of soluble (s)IL-2Rs, the pre- and postdexamethasone phytohemagglutinin (PHA)-induced accumulation of sIL-2Rs in culture supernatant, and the number of T helper (CD4+) and T suppressor (CD8+) cells. In comparison with normal volunteers, patients with major depression had a higher number and percentage of CD25+ cells, higher concentrations of serum circulating sIL-2Rs, higher supernatant sIL-2Rs after stimulation with PHA, and a higher number of CD4+ cells. The CD4+/CD8+ ratio and the number of CD4+ cells were significantly and positively related to the number of cells expressing the CD25+ antigen. These results may indicate that depressed patients display an increased number of T cells in an early phase of activation.
Keywords: Adult CD4-CD8 Ratio Depressive Disorder/GENETICS/*IMMUNOLOGY/PSYCHOLOGY Dexamethasone/DIAGNOSTIC USE Female Gene Expression Regulation/*PHYSIOLOGY Human Leukocyte Count Lymphocyte Transformation/*GENETICS/IMMUNOLOGY Male Middle Age Receptors, Interleukin-2/*GENETICS T-Lymphocyte Subsets/*IMMUNOLOGY Up-Regulation (Physiology)/*GENETICS JOURNAL ARTICLEKWDadultcd4-cd8ratiodepressivedisorder/genetics/KWDimmunology/psychologydexamethasone/diagnosticusefemalegeneexpressionregulation/KWDphysiologyhumanleukocytecountlymphocytetransformation/KWDgenetics/immunologymalemiddleagereceptors,interleukin-2/KWDgeneticst-lymphocytesubsets/KWDimmunologyup-regulation(physiology)/KWDgeneticsjournalarticle
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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