Adenovirus encephalitis and widespread ependymitis in a child with AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Adenovirus encephalitis and widespread ependymitis in a child with AIDS.

Pediatr Neurosurg. 1990-91;16(6):316-20. Unique Identifier : AIDSLINE MED/92207792
Anders KH; Park CS; Cornford ME; Vinters HV; Department of Pathology (Neuropathology), UCLA Medical Center.

Abstract: A 4-year-old child with AIDS developed encephalitis 2 months prior to death. Adenovirus was cultured from the cerebrospinal fluid. At autopsy, sections of the brain revealed complete sloughing of the intracranial ependyma, with marked gliosis and edema of the periventricular white matter. Cells with large, dark, smudgy intranuclear inclusions, consistent with adenovirus inclusions, were also seen in subependymal locations. In situ hybridization studies confirmed the presence of adenovirus DNA in these cells. This represents a case of morphologically proven adenovirus encephalitis in a pediatric AIDS patient.
Keywords: Adenovirus Infections, Human/*PATHOLOGY AIDS Dementia Complex/*PATHOLOGY Brain/PATHOLOGY Case Report Child, Preschool DNA Probes Encephalitis/*PATHOLOGY Ependyma/*PATHOLOGY Human Inclusion Bodies/ULTRASTRUCTURE Male Opportunistic Infections/*PATHOLOGY Spinal Cord/PATHOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDadenovirusinfections,human/KWDpathologyaidsdementiacomplex/KWDpathologybrain/pathologycasereportchild,preschooldnaprobesencephalitis/KWDpathologyependyma/KWDpathologyhumaninclusionbodies/ultrastructuremaleopportunisticinfections/KWDpathologyspinalcord/pathologysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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