[Meningitis associated with tsutsugamushi disease--detection of intrathecal interferon-gamma synthesis and lymphocyte subsets in blood and CSF] NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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[Meningitis associated with tsutsugamushi disease--detection of intrathecal interferon-gamma synthesis and lymphocyte subsets in blood and CSF]

Rinsho Shinkeigaku. 1991 Oct;31(10):1103-6. Unique Identifier : AIDSLINE MED/92200752
Ikeda M; Sato T; Takahashi H; Yoshida S; Tsukagoshi H; Department of Neurology, Asahi General Hospital.

Abstract: We report a case of meningitis associated with tsutsugamushi disease. The lymphocyte subpopulation study of peripheral blood revealed a reversed CD4/CD8 ratio (0.14), an increased number of activated T cells and an elevated cytotoxic T cell activity. In cerebrospinal fluid (CSF), the CD4/CD8 ratio was much higher (0.84) and activated T cells were less prevalent than in blood. These pictures of lymphocyte subsets were characteristic and different from that of viral meningitis. We also verified an elevation of interferon-gamma levels in CSF as well as in serum and intrathecal interferon-gamma synthesis while the specific antibody production in CSF compartment was not demonstrated. T cell-mediated immunity many play an important role not only systemically but also locally in the central nervous system in tsutsugamushi disease.
Keywords: Case Report Central Nervous System/*METABOLISM CD4-CD8 Ratio English Abstract Human Interferon Type II/*BIOSYNTHESIS/CEREBROSPINAL FLUID *Lymphocyte Subsets Male Meningitis, Bacterial/*IMMUNOLOGY/METABOLISM Middle Age Scrub Typhus/*IMMUNOLOGY/METABOLISM JOURNAL ARTICLEKWDcasereportcentralnervoussystem/KWDmetabolismcd4-cd8ratioenglishabstracthumaninterferontypeii/KWDbiosynthesis/cerebrospinalfluidKWDlymphocytesubsetsmalemeningitis,bacterial/KWDimmunology/metabolismmiddleagescrubtyphus/KWDimmunology/metabolismjournalarticle
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M9271059

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