[A case of HTLV-1 associated myelopathy and adult T-cell leukemia, presenting unique muscle pathology including rimmed vacuole] NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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[A case of HTLV-1 associated myelopathy and adult T-cell leukemia, presenting unique muscle pathology including rimmed vacuole]

Rinsho Shinkeigaku. 1991 Oct;31(10):1129-34. Unique Identifier : AIDSLINE MED/92200757
Honma S; Yamada K; Moriwaka F; Shima K; Tashiro K; Department of Neurology, Hokkaido University School of Medicine.

Abstract: A 63-year-old man developed muscular atrophy and weakness in his four extremities since 1983, and was pointed out to have smoldering ATL by elevated HTLV-1 antibody titers in the serum (x 2,500) and CSF (x 32) in 1985. Neurological examinations revealed proximal muscular weakness and atrophy of four extremities, and mild spasticity of both legs. Deep tendon reflexes were hypoactive in both arms and hyperactive in both lower extremities with ankle clonus and bilateral positive Babinski and Chaddock reflexes. These findings were compatible with HAM. His gait, however, was markedly waddling, requiring support. Muscle biopsy at left biceps muscle revealed inflammatory change with rimmed vacuoles, small group atrophy, and marked type 1 fiber predominance. These findings on muscle biopsy are different from those of previously reported cases with HAM, showing some similarities to inclusion body myositis or distal myopathy with rimmed vacuole.
Keywords: Biopsy Case Report English Abstract Human Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/ *COMPLICATIONS Male Middle Age Muscles/*PATHOLOGY Paraparesis, Tropical Spastic/*COMPLICATIONS/PATHOLOGY Vacuoles/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW OF REPORTED CASESKWDbiopsycasereportenglishabstracthumanleukemia-lymphoma,t-cell,acute,htlv-i-associated/KWDcomplicationsmalemiddleagemuscles/KWDpathologyparaparesis,tropicalspastic/KWDcomplications/pathologyvacuoles/pathologyjournalarticlereviewreviewofreportedcases
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