The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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The SCID-hu mouse: a small animal model for HIV infection and pathogenesis.

Annu Rev Immunol. 1991;9:399-429. Unique Identifier : AIDSLINE MED/92000510
McCune J; Kaneshima H; Krowka J; Namikawa R; Outzen H; Peault B; Rabin L; Shih CC; Yee E; Lieberman M; et al; SyStemix, Inc., Palo Alto, California 94303.

Abstract: The SCID-hu mouse is a heterochimeric small animal model designed to support hematopoietic differentiation and function in vivo. Multiple organs of the human hematolymphoid system have been successfully engrafted into the immunodeficient C.B-17 scid scid mouse, including fetal liver, thymus, lymph node, and skin. Co-implantation of human fetal liver and human fetal thymus results in long-term, multilineage human hematopoiesis in vivo. Mature human lymphocytes within the SCID-hu mouse are phenotypically and functionally normal. HIV infection of the SCID-hu mouse reflects a tropism similar to that found in humans: only human organs with CD4+ cells are infected. Viral replication can thereafter be monitored with assays that are safe, reproducible, and quantitative. Given this small animal model, it is now possible to study systematically the infective process of HIV and to address questions about the efficacy of novel antiviral compounds or vaccines in vivo.
Keywords: Animal Chimera Disease Models, Animal Hematopoiesis Hematopoietic System/IMMUNOLOGY Human HIV Infections/*ETIOLOGY/THERAPY Immunologic Deficiency Syndromes/ETIOLOGY Lymphoid Tissue/TRANSPLANTATION Mice JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalchimeradiseasemodels,animalhematopoiesishematopoieticsystem/immunologyhumanhivinfections/KWDetiology/therapyimmunologicdeficiencysyndromes/etiologylymphoidtissue/transplantationmicejournalarticlereviewreview,tutorial
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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