Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukaemia/lymphoma: implications for the mechanism of hypercalcaemia.

Br J Cancer. 1991 Oct;64(4):745-8. Unique Identifier : AIDSLINE MED/92001312
Moseley JM; Danks JA; Grill V; Lister TA; Horton MA; St Vincent's Institute of Medical Research, Fitzroy, Victoria,; Australia.

Abstract: The infiltrated tissues from seven West Indian patients with HTLV-1 positive adult T cell lymphoma/leukaemia (ATLL) have been analysed by immunocytochemical techniques for the presence of immunoreactive parathyroid hormone-related protein (PTHrP), a hormonal mediator of humoral hypercalcaemia of malignancy. Six of the seven were hypercalcaemic at some stage of the course of their disease. Four of the six evaluable patients showed evidence of specific cellular and extracellular expression of PTHrP protein in neoplastic tissues. This finding suggests that PTHrP may be involved in the production of hypercalcaemia in at least some cases of T cell lymphoma - proof of a causal relationship however must await the demonstration of tissue release of PTHrP resulting in raised circulating hormone levels.
Keywords: Adult Female Human Hypercalcemia/BLOOD Immunohistochemistry *Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/BLOOD/ PATHOLOGY Male Middle Age Neoplasm Proteins/*ANALYSIS Parathyroid Hormones/*ANALYSIS Proteins/*ANALYSIS Support, Non-U.S. Gov't JOURNAL ARTICLE

KWDadultfemalehumanhypercalcemia/bloodimmunohistochemistryKWDleukemia-lymphoma,t-cell,acute,htlv-i-associated/blood/pathologymalemiddleageneoplasmproteins/KWDanalysisparathyroidhormones/KWDanalysisproteins/KWDanalysissupport,non-uKWDsKWDgov'tjournalarticle
920130
M9210736

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