Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells.

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-I-infected cells.

Int Immunol. 1991 Aug;3(8):761-7. Unique Identifier : AIDSLINE MED/92001744
Kannagi M; Harada S; Maruyama I; Inoko H; Igarashi H; Kuwashima G; Sato S; Morita M; Kidokoro M; Sugimoto M; et al; Department of Biodefence and Medical Virology, Kumamoto; University Medical School, Japan.

Abstract: We established long-term cell lines of cytotoxic T lymphocytes (CTL) specific for human T cell leukemia virus type I (HTLV-I) from peripheral blood lymphocytes (PBL) of a patient with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an HTLV-I-carrier with Sjogren syndrome, and an asymptomatic HTLV-I-carrier, by repeated stimulation with autologous HTLV-I-infected T cells in vitro. CTL derived from the patient with HAM/TSP expressed CD8 antigen, and their function was restricted by HLA-A2. They showed cytotoxic effects predominantly against the target cells expressing HTLV-I p40tax among the autologous B cell lines infected with vaccinia recombinants containing various HTLV-I genes which served as targets. These data are consistent with the previously reported findings that fresh PBL of HAM/TSP patients contain p40tax-specific CTL activity. Furthermore, CTL derived from the patient with Sjogren syndrome without neurological involvement also demonstrated cytotoxicity predominantly to p40tax. The cytotoxicity to the target cells experimentally expressing p40tax was blocked by unlabeled HTLV-I-infected cells possessing HLA-A2. HTLV-I-specific cytotoxicity was also inhibited by unlabeled B cells bearing p40tax. Thus, HTLV-I p40tax-specific cytotoxicity is mediated by the major CTL population activated by native HTLV-I antigens in patients with HAM/TSP or Sjogren syndrome. In contrast to the CTL of these patients, CTL similarly induced from the asymptomatic HTLV-I-carrier, which were highly cytotoxic to autologous HTLV-I-infected T cells, did not show significant levels of cytotoxicity to autologous B cells expressing p40tax.(ABSTRACT TRUNCATED AT 250 WORDS)

Keywords: Adult Antigens, CD8/*ANALYSIS B-Lymphocytes/IMMUNOLOGY Cell Line Female Gene Products, tax/*IMMUNOLOGY Human HLA-A2 Antigen/IMMUNOLOGY HTLV-I Infections/*IMMUNOLOGY Paraparesis, Tropical Spastic/*IMMUNOLOGY Phenotype Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic/*IMMUNOLOGY JOURNAL ARTICLE

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