PAPILLOMAVIRUS GENITAL INFECTION AND SEROPOSITIVITY: HIGH INCIDENCE OF MULTICENTRIC HUMAN PAPILLOMAVIRUS INFECTIONS OF THE GENITAL TRACT IN HIV SEROPOSITIVE WOMEN

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

PAPILLOMAVIRUS GENITAL INFECTION AND SEROPOSITIVITY: HIGH INCIDENCE OF MULTICENTRIC HUMAN PAPILLOMAVIRUS INFECTIONS OF THE GENITAL TRACT IN HIV SEROPOSITIVE WOMEN

Serono Symp Publ Raven; 78:203-6 1990. Unique Identifier : AIDSLINE ICDB/92678065
Caubel P; Foulques H; Blondon J; Lefranc JP; Dept. of Gynecology, Salpetriere Hosp., 47 Boulevard de; l'Hopital, 75651 Paris Cedex 13, France

Abstract: Recent findings have suggested a high prevalence of cervical human papillomavirus (HPV) infections and/or cervical intraepithelial neoplasia (CIN) in HIV-seropositive women. Moreover, it has been established that HPV infection of the female genital tract frequently is multicentric in the general population with CIN. Sixty consecutive confirmed HIV-infected women were investigated for evidence of CIN and vulvar intraepithelial neoplasia. The mean age of the group was 28.2 yr (range: 19-67 yr). Forty cervical smears (66.7%) showed evidence of HPV infection either isolated (40%) or associated with CIN (26.7%). Colposcopic patterns suggested HPV infection in 77.4% of the examined patients. Macroscopic examination of the vulva showed genital warts in 21 patients, 3 of whom had associated herpes virus infection. Small vulvar lesions that were barely visible macroscopically were best accessed using the colposcope after addition of 5% acetic acid. Four papillae, 5 leucoplakiae, and 11 acetowhite reactions were diagnosed. The frequency of HPV infections found in this series emphasizes the importance of their diagnosis and treatment in HIV-seropositive women. Transformation of cervical carcinoma in situ to invasive cancer may be rapid. Conversely, the potential for transformation of vulvar HPV lesions is small. However, microtrauma and irritation caused by vulvar lesions may be a risk factor for the transmission of HIV during sexual intercourse. This may be an argument for treating vulvar as well as cervical lesions. (8 Refs)

Keywords: Adult Aged Biopsy Carcinoma, Squamous Cell/COMPLICATIONS Cervix Neoplasms/*COMPLICATIONS Female Human HIV Seropositivity/*COMPLICATIONS Middle Age Neoplasms, Multiple Primary/*COMPLICATIONS Opportunistic Infections/*COMPLICATIONS *Papillomavirus Precancerous Conditions/COMPLICATIONS Risk Factors Tumor Virus Infections/*COMPLICATIONS Vaginal Smears Vulva/PATHOLOGY Vulvar Neoplasms/*COMPLICATIONS MONOGRAPH
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M9220892

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