WORKSHOP ON NEOPLASTIC TRANSFORMATION IN HUMAN CELL SYSTEMS IN VITRO: MECHANISMS OF CARCINOGENESIS. APRIL 25-26, 1991, WASHINGTON, DC NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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WORKSHOP ON NEOPLASTIC TRANSFORMATION IN HUMAN CELL SYSTEMS IN VITRO: MECHANISMS OF CARCINOGENESIS. APRIL 25-26, 1991, WASHINGTON, DC

Workshop on Neoplastic Transformation in Human Cell Systems In Vitro: Mechanisms of Carcinogenesis. April 25-26, 1991, Washington, DC, 1991.. Unique Identifier : AIDSLINE ICDB/92678294
Anonymous; No affiliation given

Abstract: A workshop on Neoplastic Transformation in Human Cell Systems In Vitro, held April 25-26, 1991 at Georgetown University Medical Center in Washington, DC, aimed to present state-of-the-art data on human cell transformations in culture and to provide insight into the conversion of normal cells to a neoplastic state. Invited lectures were followed by discussion, and posters presented additional new information. These topics were included: an overview of neoplastic transformation in human cell systems, cellular senescence and cancer, deficient DNA repair (an early step in neoplastic transformation), immortalized human keratinocytes for study of squamous differentiation and mutagenesis, in vitro transformation of human liver cells by SV10 large T antigen, characterization of mutagen-activated genes that confer anchorage-independence to human fibroblasts, cytoskeletal changes in transformed cells (studies on HOS cells), transformation of human diploid fibroblasts by radiation and oncogenes, x-ray-induced protein kinase activation mediates proto-oncogene JUN expression, transforming genes from radiation-induced neoplastic human epidermal keratinocytes detected by a tumorigenicity assay, neoplastic transformation of human epithelial cells by ionizing radiation, an inherited p53 point mutation in a cancer-prone family with Li-Fraumeni syndrome, p53 as a direct target of mutational activation by chemical carcinogens, role of HIV tat gene in transformation of human keratinocytes in culture and induction of tumors in transgenic mice, immortalization and tumorigenic transformation of normal human cervical epithelial cells transfected with human papillomavirus DNAs, transformation of human genital and respiratory epithelial cells by E6 and E7 genes of papillomavirus, molecular pathogenesis of Epstein-Barr virus transformation of B lymphocytes, isolation and characterization of a transforming DNA sequence in human nasopharyngeal carcinoma cells, SV40 T antigen immortalization and HST-1 oncogene transformation of human esophageal epithelial cells, phenotypic plasticity of human tumorigenic cells (role of chemicals and oncogenes in transformation of nontumorigenic human cells), altered regulation of growth and differentiation at different stages of transformation of human skin keratinocytes, in vitro human mammary epithelial model system for study of differentiation and carcinogenesis, tumor progression in human breast cancer, mitogen-independence via an autocrine mechanism by oncogene-transfected diploid human mesothelial cells, transformation of human tracheal gland epithelial cell cultures, malignant transformation of human fibroblasts in vitro, multiple steps in in vitro immortalization and neoplastic conversion of human colonic epithelial cells, utilization of SV40 T antigen 'immortalized' human bronchial epithelial cells for studies of positive and negative growth controls, multistep transformation in vitro of human urothelial cells by SV40 virus and human bladder carcinogens or mutant EJ/RAS, and a nontumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.
Keywords: Animal Cell Line *Cell Transformation, Neoplastic Cells, Cultured *Genes, Suppressor, Tumor Human Neoplasms/*GENETICS *Oncogenes Retroviridae/GENETICS Transfection MONOGRAPHKWDanimalcelllineKWDcelltransformation,neoplasticcells,culturedKWDgenes,suppressor,tumorhumanneoplasms/KWDgeneticsKWDoncogenesretroviridae/geneticstransfectionmonograph
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M9220884

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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