HUMAN PAPILLOMA VIRUS IN HIV SEROPOSITIVE WOMEN: THE EFFECT OF IMMUNE STATUS ON VIRAL DETECTION (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

HUMAN PAPILLOMA VIRUS IN HIV SEROPOSITIVE WOMEN: THE EFFECT OF IMMUNE STATUS ON VIRAL DETECTION (MEETING ABSTRACT)

Proceedings of the Felix Rutledge Society Twenty-Second Annual Meeting. May 23-25, 1991, Houston, TX p. 13, 1991.. Unique Identifier : AIDSLINE ICDB/92678533
Burnett A; Johnson J; Young M; Willett G; Potkul RK; Barnes W; Doniger J; Delgado G; Georgetown Univ. Medical Center, Washington, DC

Abstract: Thirty-two HIV-infected women were examined for evidence of occult human papillomavirus infection. Cervical cytology, Virapap, screening colposcopy, and biopsies of suspicious lesions were performed on all patients (pts). Immune status was assessed with absolute CD4 cell count. Human immunodeficiency virus infection was documented by ELIZA and Western blot. The av age of the pts was 34 yr (20-64). Cervical HPV infection was detected in 14 of 32 pts: 5 were positive by both Virapap and Papanicolaou smear, 2 had positive pap smear only, and 6 were positive by Virapap alone. Of the 11 Virapap positives, there were 2 positive for HPV 6/11, 7 positive for HPV 16/18, and 4 positive for HPV 31/33/35 (2 pts were positive for more than one category of Virapap). Cervical intraepithelial neoplasia was detected by cytology in 7 pts, 5 of whom were positive for HPV DNA. The mean CD4 count for all subjects was 318, however, the mean for those who were positive for HPV by Virapap testing was 141 as compared with 416 for the Virapap negative group (p = 0.0002). The 2 groups did not vary in cytologic or histopathic incidence of HPV or dysplasia. These data suggest that HIV seropositive women are at risk for harboring human papillomavirus and that this risk appears to be greater with diminished immunocompetence. In addition, this study reveals a high incidence of carcinogenic HPV types. HIV seropositive woman may require closer surveillance for cervical disease. Further studies are warranted.

Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/IMMUNOLOGY Cervix Neoplasms/*COMPLICATIONS/MICROBIOLOGY DNA, Viral/ISOLATION & PURIF Female Human HIV Infections/*COMPLICATIONS/IMMUNOLOGY *HIV Seropositivity Papillomavirus/*ISOLATION & PURIF Risk Factors Tumor Virus Infections/*COMPLICATIONS Vaginal Smears ABSTRACT
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M9220882

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