[Glycosphingolipids affect on the functional properties of human lymphocytes--in relation to HIV-infection of lymphocytes] NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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[Glycosphingolipids affect on the functional properties of human lymphocytes--in relation to HIV-infection of lymphocytes]

Hum Cell. 1989 Mar;2(1):45-50. Unique Identifier : AIDSLINE MED/92031238
Nakakuma H; Kawaguchi T; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.

Abstract: Glycosphingolipids, which are functionally present on plasma membrane of mammalian cells, have a variety of functions in immune system such as surface markers of lymphocytes and mediators or modulators of the cells. Interestingly, gangliosides induced selective modulation of CD4, which is not only the subset marker of T-lymphocytes but also the receptor for human immunodeficiency virus. Here, we raised a process of endocytosis as a possible mechanism for the modulation of CD4. We also found that gangliosides inhibited HIV-infection in vitro.
Keywords: Animal Antigens, CD4/IMMUNOLOGY/METABOLISM Cells, Cultured Endocytosis English Abstract Gangliosides/*PHYSIOLOGY Human HIV/*IMMUNOLOGY Receptors, Virus T-Lymphocytes/*IMMUNOLOGY/METABOLISM JOURNAL ARTICLEKWDanimalantigens,cd4/immunology/metabolismcells,culturedendocytosisenglishabstractgangliosides/KWDphysiologyhumanhiv/KWDimmunologyreceptors,virust-lymphocytes/KWDimmunology/metabolismjournalarticle
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Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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