Cisplatin stimulates the expression from the human immunodeficiency virus long terminal repeat sequences in human fibroblasts. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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Cisplatin stimulates the expression from the human immunodeficiency virus long terminal repeat sequences in human fibroblasts.

Anticancer Drugs. 1990 Oct;1(1):55-8. Unique Identifier : AIDSLINE MED/92032985
Zoumpourlis V; Patsilinacos P; Kotsinas A; Maurer HR; Lenas P; Spandidos DA; Institute of Biological Research and Biotechnology, National; Hellenic Research Foundation, Athens, Greece.

Abstract: A recombinant plasmid carrying the long terminal repeat (LTR) of the human immunodeficiency virus 1 (HIV-1) linked to the reporter chloramphenicol acetyl transferase (CAT) gene was stably introduced into human fibroblasts. The transfectant cells expressed CAT activity from the HIV LTR. The response to anti-neoplastic drugs, i.e. cisplatin, a platin derivative, and hexadecylphosphocholine, was studied. It was found that at 5 x 10(-6) M concentrations cisplatin stimulates by 2.2-fold the expression of CAT from the HIV LTR. Our results extend our observations on the effect of cisplatin on HIV LTR in rodent fibroblast cells and suggest caution against therapy including cisplatin in the treatment of AIDS patients.
Keywords: Antineoplastic Agents/PHARMACOLOGY Cells, Cultured Cisplatin/ADVERSE EFFECTS/*PHARMACOLOGY Fibroblasts/DRUG EFFECTS/*PHYSIOLOGY Gene Expression/DRUG EFFECTS Human HIV-1/*GENETICS Plasmids Repetitive Sequences, Nucleic Acid/*DRUG EFFECTS/GENETICS Stimulation, Chemical Transcription, Genetic/DRUG EFFECTS Transfection JOURNAL ARTICLEKWDantineoplasticagents/pharmacologycells,culturedcisplatin/adverseeffects/KWDpharmacologyfibroblasts/drugeffects/KWDphysiologygeneexpression/drugeffectshumanhiv-1/KWDgeneticsplasmidsrepetitivesequences,nucleicacid/KWDdrugeffects/geneticsstimulation,chemicaltranscription,genetic/drugeffectstransfectionjournalarticle
920228
M9220858

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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