HIV proteins in normal human placentae. NLM AIDSLINE Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

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HIV proteins in normal human placentae.

Am J Reprod Immunol. 1991 Apr;25(3):99-104. Unique Identifier : AIDSLINE MED/92029534
Faulk WP; Labarrere CA; Center for Reproduction and Transplantation Immunology, Methodist; Hospital of Indiana, Indianapolis 46202.

Abstract: Cryostat sections of human normal term placentae were studied for evidence of immunopathology by using antibodies to lymphocytes, macrophages, platelets, and coagulation factors. Areas of so-called chronic villitis of unestablished etiology were identified in all placentae. The same tissues were examined for HIV protein antigens gp120, p17, p24, and gp41. No evidence for gp41 was found. Antigens gp120 and p17 were identified in normal chorionic villi in vimentin-positive fibroblast-like cells and in endothelium, respectively. Antigen p24 was localized to HLA-DR positive cells that morphologically resembled macrophages in areas of villitis. The distribution of gp120 and p17 was similar to that observed for tissue factor. These findings prompted speculation that retroviral proto-oncogenes that are known to encode for certain placental receptors could be involved in the presentation of tissue factor, and that gp120 may be a hitherto unrecognized immunobiological mechanism for the blockade of CD4 on maternal lymphocytes if and when such cells gain entrance to chorionic villi.
Keywords: Chorionic Villi/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Endothelium/MICROBIOLOGY Female Fibroblasts/MICROBIOLOGY Fluorescent Antibody Technique Human HIV Core Protein p24/ANALYSIS HIV Envelope Protein gp120/ANALYSIS HIV Envelope Protein gp41/ANALYSIS HIV Infections/IMMUNOLOGY/*MICROBIOLOGY Macrophages/MICROBIOLOGY Placenta/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Pregnancy Support, Non-U.S. Gov't Viral Proteins/*ANALYSIS JOURNAL ARTICLEKWDchorionicvilli/immunology/KWDmicrobiology/pathologyendothelium/microbiologyfemalefibroblasts/microbiologyfluorescentantibodytechniquehumanhivcoreproteinp24/analysishivenvelopeproteingp120/analysishivenvelopeproteingp41/analysishivinfections/immunology/KWDmicrobiologymacrophages/microbiologyplacenta/immunology/KWDmicrobiology/pathologypregnancysupport,non-uKWDsKWDgov'tviralproteins/KWDanalysisjournalarticle
920228
M9220841

Copyright © 1992 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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