MRI AND NEUROLOGICAL COMPLICATIONS OF ADULT T-CELL LEUKEMIA (MEETING ABSTRACT)

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

MRI AND NEUROLOGICAL COMPLICATIONS OF ADULT T-CELL LEUKEMIA (MEETING ABSTRACT)

Neuroradiology; 33(Suppl):S160 1991. Unique Identifier : AIDSLINE ICDB/92686345
Dumas JL; Visy JM; Brugieres P; Lhote F; Vassel P; Amouroux J; Goldlust D; Inst. of Tropical Neurology, Dept. of Medicine, Limoges, France

Abstract: Our purpose was the MRI assessment of a lumbosacral localization of adult T-cell leukemia with HTLV-1 infection and search of CNS-associated involvement. Materials and methods: A 21-yr-old woman from Ivory Coast presented a meningoradiculopathy with adult T-cell leukemia-like cells in cerebrospinal fluid. Antibodies to HTLV-1 were positive in serum and CSF. She underwent lumbar spinal cord MRI (1.5-T unit) with pre- and postcontrast medium sagittal and axial T1-weighted sequences before and after treatment. Brain MRI was performed with axial and coronal T2-weighted sequences. Results: MRI revealed a conus medullaris pia mater enhancement extended to proximal spinal roots suggestive of lymphomatous infiltration. After polychemotherapy, we observed a complete disappearance of the enhancement. Brain MRI detected multifocal lesions of increased signal intensity in the subcortical white matter. Conclusion: MRI displays the direct infiltration by tumor cells and is necessary to characterize an associated subclinical impairment of CNS. It is important to underline that brain MR findings are similar to those observed in HTLV-1-associated myelopathy. These MRI abnormalities are compatible with reported necropsy findings in cases of adult T-cell leukemia with neurological complications and have not been reported in literature.

Keywords: Adult Brain/RADIOGRAPHY Case Report Female Human Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/COMPLICATIONS/ *RADIOGRAPHY Lumbosacral Region/RADIOGRAPHY Magnetic Resonance Imaging ABSTRACT
921230
M92C5378

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